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課程名稱 |
分子演化
Molecular Evolution |
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開課學期 |
104-2 |
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授課對象 |
生命科學院 生命科學所 |
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授課教師 |
丁照棣 |
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課號 |
EEB5048 |
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課程識別碼 |
B44EU1600 |
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班次 |
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學分 |
2 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三3,4(10:20~12:10) |
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上課地點 |
生科419 |
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備註 |
本課程以英語授課。與胡哲明合開
總人數上限：40人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1042MolEvol |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
This course is designed for undergraduate level students who are interested in molecular evolution or bioinformatics related topics. Students who have some knowledge of biology and/or genetics are preferred. The instructors will introduce the dynamics of evolutionary change at the molecular level, the driving forces govern the evolutionary process, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes, the methodology involved in dealing with molecular data from an evolutionary perspective, and the logic of molecular hypothesis testing.
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課程目標 |
In combination with the computer laboratory practice, we aim to help our students to understand the evolutionary processes at the molecular level. |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
每週三 12:10~13:00 備註： by appointment |
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指定閱讀 |
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參考書目 |
Bioinformatics and Molecular Evolution by Paul Higgs and Teresa Attwood (Wiley-Blackwell, 2005)
Computational Molecular Evolution by Ziheng Yang (Oxford University Press, 2006)
Inferring Phylogenies (Paperback) by Joseph Felsenstein (Sinauer, 2003)
Molecular Evolution and Phylogenetics by Masatoshi Nei and Sudhir Kumar (Oxford University Press, 2000)
Molecular Evolution by Wen-Hsiung Li (Sinauer Associates, 1997)
Molecular Evolution: A Phylogenetic Approach by Roderick D.M. Page and, Edward C. Holmes (1991, Wiley-Blackwell)
Phylogenetic Trees Made Easy: A How-to Manual, Third Edition by Barry G. Hall (Sinauer, 2007)
Statistical Methods in Molecular Evolution by Rasmus Nielsen (Springer, 2005)
The Phylogenetic Handbook: A Practical Approach to DNA and Protein Phylogeny Ed. by Marco Salemi and Anne-Mieke Vandamme (Cambridge University Press, 2003)
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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Week 1 |
2/24 |
[Lecture] Introduction, The Molecular Basis of Biology and Evolution (Ch1) |
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Week 2 |
3/02 |
[Lecture] Introduction: The Revolution in Biological Information
[Computer Lab] Sequence retrieval, Sequence alignment (ClustalW) |
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Week 3 |
3/09 |
[Lecture] Allele Dynamics in Populations (Ch2) |
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Week 4 |
3/16 |
[Lecture] DNA and Amino Acid Sequence Evolution (Ch3) |
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Week 5 |
3/23 |
[Lecture] Rates and Patterns of Molecular Evolution (I) (Ch4)
[Computer Lab] Estimating nucleotide substitution (MEGA) |
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Week 6 |
3/30 |
[Lecture] Rates and Patterns of Molecular Evolution (II) (Ch4) |
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Week 7 |
4/06 |
[Lecture] Molecular Phylogenetics and Phylogenetic Trees (I) (Ch5) |
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Week 8 |
4/13 |
[Lecture] Molecular Phylogenetics and Phylogenetic Trees (II) (Ch5) |
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Week 9 |
4/20 |
[Lecture] Reticulate Evolution and Phylogenetic Networks (Ch6) |
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Week 10 |
4/27 |
[Computer Lab] Phylogenetic Inference (I) |
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Week 11 |
5/04 |
[Lecture] Experimental Molecular Evolution (Ch13) |
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Week 12 |
5/11 |
[Computer Lab] Phylogenetic Inference (II) |
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Week 13 |
5/18 |
[Lecture] Evolution by DNA Duplication/ Evolution by Molecular Tinkering (Ch7/8) |
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Week 14 |
5/25 |
[Lecture] Mobil Elements in Evolution (Ch9) |
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Week 15 |
6/01 |
Final project week [no class] |
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Week 16 |
6/08 |
[Lecture] Prokaryotic Genome Evolution (Ch10) |
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Week 17 |
6/15 |
[Student's Presentation] Final Project |
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